长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展
投稿时间:2019-04-04  修订日期:2019-06-11  点此下载全文
引用本文:丁佳宁,马进原,朱全刚.长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展[J].药学实践杂志,2019,37(5):390~393,421
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作者单位E-mail
丁佳宁 上海中医药大学附属岳阳中西医结合医院药学研究室, 上海 200437  
马进原 上海市皮肤病医院药剂科, 上海 200443  
朱全刚 上海中医药大学附属岳阳中西医结合医院药学研究室, 上海 200437
上海市皮肤病医院药剂科, 上海 200443 
qgzhu@126.com 
基金项目:国家自然科学基金(81472394);上海市皮肤病医院国家自然科学基金培育项目(17GZRPY11)
中文摘要:长链非编码RNA(long non-coding RNA,lncRNA)覆盖了人类DNA的大部分非编码信息,占整个基因组的90%以上,它们构成了一个广泛而复杂的分子群,在肿瘤的病理生理过程中以多种形式存在。2003年,lncRNA人母系表达基因(MEG)3被证明是垂体瘤的一个潜在的肿瘤抑制因子,之后研究者又在脑膜瘤、肝癌、肺癌、神经内分泌瘤,以及前列腺癌等其他肿瘤上对其在基因表达调控、印记、转录和翻译后的作用上进行了研究,发现MEG3在多种恶性肿瘤组织中低表达或表达缺失,而上调MEG3的表达与肿瘤生长抑制相关,其在肿瘤发生中的作用和机制得到了更好地阐明。总结MEG3的功能及在肿瘤发生中的研究进展。
中文关键词:长链非编码RNA  人母系表达基因3  表观遗传  肿瘤  抑癌基因
 
Research progress of lncRNA MEG3 in tumorigenesis
Abstract:Long non-coding RNA (lncRNA) covers most of the messages from the human DNA without protein-coding potential,which is a wide range of complicated molecules that consist of more than 90% of the whole genomic and present in different forms in the course of pathophysiology of cancers.In 2003,lncRNA MEG3 was firstly discovered as a potential tumor-inhibiting factor of pituitary adenomas.Later on,the roles and mechanisms in the regulation of gene expression,imprinting,transcription,and post-translation of MEG3 in meningioma,hepatocellular cancer,lung cancer,neuroendocrine tumor,prostate cancer and other kinds of tumors were further clarified,indicated that the expression of MEG3 was down-regulated or deficient in a wide range of tumors while the expression up-regulation of MEG was greatly correlated with tumor inhibition.The function of MEG3 and its research progress in tumorigenesis were summarized in this paper.
keywords:lncRNA  MEG3  epigenetic regulation  tumor  antioncogene
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