异甘草酸镁治疗抗结核药物所致肝损伤疗效的Meta分析
投稿时间:2019-01-30  修订日期:2019-05-14  点此下载全文
引用本文:阮军,尹恒,寇国先,刘茗心,杨蕊西.异甘草酸镁治疗抗结核药物所致肝损伤疗效的Meta分析[J].药学实践杂志,2019,37(4):375~379
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作者单位E-mail
阮军 四川省绵阳市中心医院 感染科, 四川 绵阳 621000 ruanjunsky@163.com 
尹恒 四川省绵阳市中心医院 肾病科, 四川 绵阳 621000  
寇国先 四川省绵阳市中心医院 感染科, 四川 绵阳 621000  
刘茗心 四川省绵阳市中心医院 感染科, 四川 绵阳 621000  
杨蕊西 四川省绵阳市中心医院 感染科, 四川 绵阳 621000  
基金项目:四川省医学会感染性肝病专项科研课题(2017SZJA 11)
中文摘要:目的 用Meta分析评价异甘草酸镁治疗抗结核药物所致肝损伤的疗效。方法 检索中国期刊全文数据库(CNKI)、维普网(VIP)、万方数据库、PubMed、EMbase与Cochrane Library,并辅以其他检索方法,纳入异甘草酸镁治疗抗结核药物所致肝损伤患者的随机对照试验(RCTs),检索截至日期为2019年4月。按照纳入和排除的标准由2名研究人员分别独立筛选文献、处理资料与评价所纳入文献的质量。Meta分析结果采用RevMan 5.2软件处理。结果 本研究全部纳入了10个RCTs,一共有823名患者。Meta分析结果表明:①异甘草酸镁可以有效治疗结核药物所致的肝损伤患者,具有统计学差异;②异甘草酸镁治疗结核药物性肝损伤时可有效改善患者的丙氨酸氨基转移酶(ALT)水平、总胆红素(TBil)水平,与对照组比较,差异有统计学意义。结论 异甘草酸镁可以有效地治疗抗结核药物所致的肝损伤患者,并促进肝功能快速恢复,但仍需更多高质量的临床研究来进一步证明。
中文关键词:异甘草酸镁  药物性肝损伤  Meta分析
 
A Meta-analysis on magnesium isoglycyrrhizinate in treatment of antituberculosis drug-induced liver injury
Abstract:Objective To evaluate the therapeutic effects of magnesium isoglycyrrhizinate in patients with antituberculosis drug-induced liver injury.Methods The literatures related to randomized controlled trials (RCT) of magnesium isoglycyrrhizinate treatment in patients with antituberculosis drug-induced liver injury were retrieved from CNKI,VIP,WanFang database,PubMed,EMbase and Cochrane Library.The collected literatures were published before April 2019.Based on the inclusive and exclusive criteria,the literatures were screened,and data were extracted by two researchers independently.Meanwhile the quality of the included studies was assessed.Meta-analysis was conducted by RevMan 5.2 software.Results 823 patients with antituberculosis drug-induced liver injury in ten RCT were enrolled.The meta-analysis demonstrated,a) compared with control group,the early-stage administration of magnesium isoglycyrrhizinate can effectively treat liver injury caused by antituberculosis drugs with statistical significance,and b) magnesium isoglycyrrhizinate can significantly reduce the alanine aminotransferase level and improve the total bilirubin level during the treatment.Conclusion Magnesium isoglycyrrhizinate administration is an effective treatment for liver injury caused by antituberculosis drugs although more high-quality researches are needed for further verification.
keywords:magnesium isoglycyrrhizinate  drug-induced liver injury  Meta-analysis
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